Is Vaccination Approaching a Dangerous Tipping Point? Peter Marks. Robert Califf. JAMA.
This Viewpoint discusses declining vaccination rates in the US, specifically against COVID-19, and the ways in which clinicians and the Food and Drug Administration can counter the current large volume of vaccine misinformation.
Source: jamanetwork.com
Discovery of a structural class of antibiotics with explainable deep learning.
One of the challenges with deep learning (neural networks) is that although they find patterns the reasoning disappears into an endless detail of numbers. In this paper the researchers built an 'explainable' AI to discover antibiotics instead of such a 'black box'. "The discovery of novel structural...
Source: nature.com
Life-threatening infections on the rise due to drug-resistant bacteria, new WHO report reveals
Over 50 per cent of life-threatening bacterial infections are becoming resistant to treatment, a new World Health Organization (WHO) report published on Friday reveals.
Source: news.un.org
FDA approves most expensive drug ever, a $3.5 million-per-dose gene therapy for hemophilia B
The single-dose medicine "represents important progress" as the first-ever gene therapy for the rare disorder, the FDA said. ”The Food and Drug Administration cleared Hemgenix, an IV treatment for adults with hemophilia B, the less common form of the genetic disorder which primarily affects men.”
Source: cbsnews.com
House passes $35-a-month insulin cap as Dems seek wider bill
WASHINGTON (AP) — The House on Thursday passed a bill capping the monthly cost of insulin at $35 for insured patients, part of an election-year push by Democrats for price curbs on prescription drugs at a time of rising inflation.
Source: apnews.com
Biopharma futures
I've been looking at a few industry reports on the future of biopharma as part of a course I'm on with INSEAD Business School on Business Strategy and Financial Performance. I thought I'd share some of my ramblings on Biopharma Futures. Expectations are high Pharmaceutical
companies are operating...
Source: deanjenkins.me
The 10 Trends Shaping the Future of Pharma - The Medical Futurist
The medical community gradually acknowledges digital health but doesn't embrace it entirely. Familiarize yourself with the future of pharma! Medical Futurist 10 trends shaping the future of pharma Patients on advisory boards - to better know the exact needs Digital health strategy 'around the pill'...
Source: medicalfuturist.com
6 expert essays on the future of biotech
How will biotechnology transform our approach to human health? Scientists from the World Economic Forum's Global Future Council share key insights. World Economic Forum future of biotech DNA technology - genetic screening for disease, recombinant protein production, CAR T cells, gene therapy, organoid...
Source: weforum.org
Biopharma 2020: A landmark year and a reset for the future
Biopharma in 2020 has shown what it can achieve when it works at its best. How can the industry build on this renewed sense of purpose in the years ahead? McKinsey biopharma 2020 3 Overarching trends Operating under a spotlight - expectation of innovationNavigating protracted economic uncertainty -...
Source: mckinsey.com
Factors affecting the uptake of new medicines: a systematic literature review - BMC Health Services Research Lublóy, Ágnes.
"This systematic literature review has provided insights into the factors that affect new drug uptake—primarily, doctors’ scientific orientation, prescribing habits, exposure to pharmaceutical marketing, and interpersonal communication." "Background The successful diffusion of new drugs is crucial...
Source: biomedcentral.com
Validation of Claims-Based Algorithms to Identify Patients with Psoriasis - PubMed Pharmacoepidemiology and drug safety.
Claims-based algorithms based on a combination of PsO diagnosis codes and dispensing for PsO-specific treatments had a moderate-to-high PPV. These algorithms can serve as a useful tool to identify patients with PsO in future real-world data pharmacoepidemiologic studies. This article is protected by...
Source: nih.gov
Quantum computing and pharmaceutical research
"Theoretically, quantum computers can prove more powerful than any supercomputer. And recent moves from computer giants such as Google and pharmaceutical titans such as Roche now suggest drug discovery might prove to be quantum computing’s first killer app." In January this year Boehringer-Ingelheim...
Source: ieee.org
How Norway is offering drug-free treatment to people with psychosis
People with psychosis are usually given powerful medication - in Norway they can now choose to go drug-free.
Source: bbc.com
Artificial intelligence yields new antibiotic
Artificial intelligence yields new antibiotic: A deep-learning model identifies a powerful new drug that can kill many species of antibiotic-resistant bacteria.
“The idea of using predictive computer models for “in silico” screening is not new, but until now, these models were not sufficiently...
Source: mit.edu
Drug therapy for delirium in terminally ill adults. Cochrane review.
Drug therapy for delirium in terminally ill adults. "terminally ill adults includes anyone with an advanced progressive illness such as advanced cancer, advanced dementia or organ failure, as well as those receiving hospice and end-of-life care ... " "We found low-quality evidence that, compared to...
Source: cochrane.org
Milasen - a drug developed for a single patient.
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease | NEJM: Summary Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the...
Source: nejm.org
Drugmaker to Test Machine Learning to Prevent Drug Shortages: Germany-based Merck plans to use analytics and machine learning
Drugmaker to Test Machine Learning to Prevent Drug Shortages: Germany-based Merck plans to use analytics and machine learning to predict and prevent drug shortages, a move that could also save it money.
Source: wsj.com
Publication bias is a challenge in science and a criticism of the influence of industry.
Publication bias is a challenge in science and a criticism of the influence of industry. In the domain of biosciences and drug development more accountability (e.g. the FDAAA 2007), editorial and peer-review training (as suggested by the Cochrane Collaboration), and statistical techniques (as championed...
German Digital Healthcare Act promotes digital health.
German Digital Healthcare Act - Frontiers Health: Bundestag adopts law on reimbursement for digital health application in Germany. "health apps, which can help patients to manage a diagnosed medical condition, can from January 2020 onwards be prescribed by their doctors. The costs are borne by the statutory...
Source: frontiers.health
Research suggests that drones could quickly deliver life-saving interventions during city
Research suggests that, in certain cases, drones could quickly deliver life-saving interventions during city’s peak rush hour. Could drones be used someday to deliver life-saving medications or interventions in the case of a child’s emergency, a drug overdose or in response to a mass casualty scene?...
Source: aap.org
RSS feed