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Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA | NEJM: Abstract Background Combination antiplatelet
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA | NEJM: Abstract Background Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reduction in the risk of recurrent stroke. We tested this combination in an international population. Methods In a randomized trial, we assigned patients with minor ischemic stroke or high-risk TIA to receive either clopidogrel at a loading dose of 600 mg on day 1, followed by 75 mg per day, plus aspirin (at a dose of 50 to 325 mg per day) or the same range of doses of aspirin alone. The dose of aspirin in each group was selected by the site investigator. The primary efficacy outcome in a time-to-event analysis was the risk of a composite of major ischemic events, which was defined as ischemic stroke, myocardial infarction, or death from an ischemic vascular event, at 90 days. Results A total of 4881 patients were en... S. Claiborne Johnston. J. Donald Easton. Mary Farrant. William Barsan. Robin A. Conwit. Jordan J. Elm. Anthony S. Kim. Anne S. Lindblad. Yuko Y. Palesch. https://doi.org/10.1056/NEJMoa1800410.
Source: www.nejm.org
ischemic aspirin stroke clopidogrel dose tia combination antiplatelet
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