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Is Exenatide a Treatment for Parkinson’s Disease? Athauda, Dilan. Wyse, Richard. Brundin, Patrik. Foltynie, Thomas. Journal
Is Exenatide a Treatment for Parkinson’s Disease? Athauda, Dilan. Wyse, Richard. Brundin, Patrik. Foltynie, Thomas. Journal of Parkinson's Disease.
"There is growing interest in the use of glucagon-like peptide-1
agonists as treatments for Parkinson’s disease following the recent
publication of the results of the Exenatide-PD trial. In this
randomized, double-blind, placebo controlled trial, patients with
moderate stage Parkinson’s disease treated
with once-weekly subcutaneous injections of exenatide 2 mg (Bydureon)
for 48 weeks, had a 3.5-point advantage over the placebo group in the
Movement Disorders Society Unified Parkinson’s Disease Rating Scale
(MDS-UPDRS) motor subscale (Part 3) in the practically defined OFF
medication state, 12 weeks after cessation of the trial drug. In this
article, we discuss some of the important issues of relevance to this
trial, with regards to trial design, patient selection, choice of
outcome measure and also place into context the implications these
results have for patients with Parkinson’s disease and the wider
research community."
Source: content.iospress.com
parkinson disease trial exenatide placebo results
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