FDA approves most expensive drug ever, a $3.5 million-per-dose gene therapy for hemophilia B
The single-dose medicine "represents important progress" as the first-ever gene therapy for the rare disorder, the FDA said. ”The Food and Drug Administration cleared Hemgenix, an IV treatment for adults with hemophilia B, the less common form of the genetic disorder which primarily affects men.”
Source: cbsnews.com
Ancient comatulid named after President Zelensky -Ausichicrinites zelenskyyi
Ancient sea animal with 10 arms is named after Ukraine's president Zelensky. "Fossil comatulids, referred to as feather stars, are mostly known from highly disarticulated
specimens. A single isolated element (centrodorsal) has been the basis for taxonomic
description of a vast majority of fossil comatulids....
Source: royalsocietypublishing.org
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16%...
Source: nature.com
Rashomon approach to medical education.
"The Rashomon approach was named after the 1950 film, Rashomon. In this film, a single event, a homicide is described from the different perspectives of the characters. In the Rashomon approach, teachers, like film directors, need to fully understand the big pictures so that they can engage characters = students...
Source: biomedcentral.com
The Technology Behind Cinematic Photos
There has been some work by teams at Google looking at analysing images to extract their 3D features. They launched a new feature called 'cinematic photos' and this blog posted by Per Karlsson and Lucy Yu, Software Engineers, of Google Research tries to explain how it works. "Looking at photos from...
Source: googleblog.com
Eeek! or E484K mutation and the coronavirus pandemic
Rupert Beale · Eeek! · LRB 19 February 2021: "Uncontrolled spread – as we knew it would – led to an even greater wave of infections, hospitalisations and deaths than last spring. Children were sent to school for one day before the necessary ‘lockdown’ was reimposed. The impulse to keep schools...
Source: lrb.co.uk
Phrase of the day: Scaling Kubernetes to 7,500 Nodes
Scaling Kubernetes to 7,500 Nodes: We've scaled Kubernetes clusters to 7,500 nodes, producing a scalable infrastructure for large models like GPT-3, CLIP, and DALL·E, but also for rapid small-scale iterative research such as Scaling Laws for Neural Language Models. Scaling a single Kubernetes cluster...
Source: openai.com
Current themes and challenges facing HPE accreditation in the 21st century
A supplement in BMC Medical Education on Health Professional Education accreditation from the community of practice The International Health Professions Accreditation Outcomes Consortium (IFPAOC) - which was founded in 2012. This supplement focuses on graduate and residency programmes but it also addresses...
Source: biomedcentral.com
Supporting migrants and refugees with posttraumatic stress disorder: development, pilot implementation, and pilot evaluation
Supporting migrants and refugees with posttraumatic stress disorder: development, pilot implementation, and pilot evaluation of a continuing interprofessional education for healthcare providers: Refugees and migrants face an increased risk of developing posttraumatic stress disorder (PTSD). Adequate...
Source: biomedcentral.com
The Sandwich principle: assessing the didactic effect in lectures on
The Sandwich principle: assessing the didactic effect in lectures on “cleft lips and palates”: A teaching concept, that takes individual learning and personal belongings into account, is called the “sandwich principle.” This didactic method is an educational concept that alternates consecutively...
Source: biomedcentral.com
Milasen - a drug developed for a single patient.
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease | NEJM: Summary Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the...
Source: nejm.org
The Collective Journey storytelling model
The Collective Journey is a way of explaining and retelling why something from the complex world has happened. Whilst it is a tool for storytellers to make compelling entertainment it also highlights the weakness of the single perspective in trying to understand the real world. “For centuries, every...
Source: collectivejourney.com
Factors associated with successful dementia education for practitioners in primary care: an in-depth case study.
Factors associated with successful dementia education for practitioners in primary care: an in-depth case study. Designing learning for person-centred care is challenging and needs to involve an approach that works with HCPs and interdisciplinary teams. “With increasing numbers of people in the UK...
Source: biomedcentral.com
Teaching a difficult topic in medical genetics using a problem-based concept resembling a computer game.
Teaching a difficult topic using a problem-based concept resembling a computer game: development and evaluation of an e-learning application for medical molecular genetics: E-learning through serious gaming. Teaching concepts such as genetic testing and the digital literacy required to analyse data can...
Source: biomedcentral.com
A Gentle Introduction to Joint, Marginal, and Conditional Probability: Probability quantifies the uncertainty of the outcomes
A Gentle Introduction to Joint, Marginal, and Conditional Probability: Probability quantifies the uncertainty of the outcomes of a random variable. It is relatively easy to understand and compute the probability for a single variable. Nevertheless, in machine learning, we often have many random variables...
Source: machinelearningmastery.com
Flare - an app that connects people and emergency response vehicles in Kenya. "How a speedy emergency services app is saving
Flare - an app that connects people and emergency response vehicles in Kenya. "How a speedy emergency services app is saving lives: Not every country has a single number to call in an emergency. One start-up is trying to change that."
Source: bbc.co.uk
A model for the use of blended learning in large group teaching sessions: Although blended learning has the potential to
A model for the use of blended learning in large group teaching sessions: Although blended learning has the potential to enhance the student experience, both in terms of engagement and flexibility, it can be difficult to effectively restructure existing courses. To achieve these goals for an introductory...
Source: biomedcentral.com
IBM Pitched Its Watson Supercomputer as a Revolution in Cancer Care. It's Nowhere Close - Slashdot: "IBM began selling
IBM Pitched Its Watson Supercomputer as a Revolution in Cancer Care. It's Nowhere Close - Slashdot: "IBM began selling Watson to recommend the best cancer treatments to doctors around the world three years ago. But is it really doing its job? Not so much. An investigation by Stat found that the supercomputer...
Source: slashdot.org
A single-centre hospital-wide handoff standardisation report: what is so special about that? "Using a relatively low-cost
A single-centre hospital-wide handoff standardisation report: what is so special about that? "Using a relatively low-cost approach, they managed to implement the system across 15 medical departments, as well as nursing, train nearly 6000 healthcare staff and collect observational data on process reliability...
Source: bmj.com
"New Software Diagnoses Cardiac Arrhythmias from ECGs Better Than Cardiologists |: Stanford researchers claim to have developed
"New Software Diagnoses Cardiac Arrhythmias from ECGs Better Than Cardiologists |: Stanford researchers claim to have developed an algorithm that "exceeds the performance of board certified cardiologists in detecting a wide range of heart arrhythmias from electrocardiograms [ECG] recorded with a single-lead...
Source: medgadget.com
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