Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
"The last 10,000 years have seen some of the most extreme global changes in lifestyle, with the emergence of farming in some regions and pastoralism in others. While 5,000 years ago farmer ancestry predominated across Europe, a relatively diverged genetic ancestry arrived with the steppe migrations around...
Source: nature.com
Discovery of a structural class of antibiotics with explainable deep learning.
One of the challenges with deep learning (neural networks) is that although they find patterns the reasoning disappears into an endless detail of numbers. In this paper the researchers built an 'explainable' AI to discover antibiotics instead of such a 'black box'. "The discovery of novel structural...
Source: nature.com
The Lyonesse Project: a study of the coastal and marine environment of the Isles of Scilly (OASIS ID cornwall2-58903)
This project was commissioned by English Heritage and carried out between 2009 and 2013 by Historic Environment Projects, Cornwall Council with a team of specialists from Aberystwyth, Cardiff, Exeter and Plymouth Universities, English Heritage's Scientific Dating Team, volunteers and local experts and...
Source: archaeologydataservice.ac.uk
Bill Gates' next generation nuclear reactor to be built in Wyoming
Billionaire Bill Gates' advanced nuclear reactor company TerraPower LLC and PacifiCorp (PPWLO.PK) have selected Wyomingto launch the first Natrium reactor project on the site of a retiring coal plant, the state's governor said on Wednesday.
Source: reuters.com
Corporate bollox generator
Over the holiday season I have been fine-tuning a new improved "corporate bollox generator" which can now deliver whole sentences of management goop. Please feel free to give it a go. It is written in Javascript and generates random phrases by linking adverbs, verbs, adjectives, and nouns all selected...
Source: agnate.co.uk
Using artificial intelligence to read chest radiographs for tuberculosis detection: A multi-site evaluation
Using artificial intelligence to read chest radiographs for tuberculosis detection: A multi-site evaluation of the diagnostic accuracy of three deep learning systems: Deep learning (DL) neural networks have only recently been employed to interpret chest radiography (CXR) to screen and triage people for...
Source: nature.com
How To Kill Ideas: We were asked last week by the Disruptive Innovators Network, 'How long should you spend on an idea?'
How To Kill Ideas: We were asked last week by the Disruptive Innovators Network, 'How long should you spend on an idea?' "In the early days of Bromford Lab we had a 12 WEEKS MAX rule. If we couldn’t get an idea up and running within that time – it should be killed. We soon realised the error of our...
Source: paulitaylor.com
The challenge of measuring real world community-based interventions. Exposure to a multi-level multi-component childhood
The challenge of measuring real world community-based interventions. Exposure to a multi-level multi-component childhood obesity prevention community-randomized controlled trial: patterns, determinants, and implications. - PubMed - NCB "Treatment effects may be attenuated in community-based trials,...
Source: nih.gov
Phrases of the day: selective exposure, selective perception, principles knowledge, vicarious trial, change agent, and cue-to-action.
Phrases of the day: selective exposure, selective perception, principles knowledge, vicarious trial, change agent, and cue-to-action. I’ve been reading Everett Rogers’ book Diffusion of Innovations with a ‘learning lens’ on. I’m fascinated that the adoption of innovations is so analogous to...
Source: amazon.co.uk
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA | NEJM: Abstract Background Combination antiplatelet
Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA | NEJM: Abstract Background Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination...
Source: nejm.org
Complexity in the evaluation of medical education - how would you evaluate this one? I am really enjoying putting together
Complexity in the evaluation of medical education - how would you evaluate this one? I am really enjoying putting together the 'current topics and controversies' week at the end of our module on 'evaluation' in the MSc/PgDip Medical Education programme at University of South Wales - though I am now...
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis: Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral anticoagulants (DOACs) for patients with atrial fibrillation.
Design...
Source: bmj.com
GPs in England 'unconfident' discussing physical activity with patients – report: Less than two-thirds of doctors feel
GPs in England 'unconfident' discussing physical activity with patients – report: Less than two-thirds of doctors feel confident discussing activity levels and almost a third have never heard of national guidelines. "The majority of doctors in England are unfamiliar with recommended
levels of physical...
Source: theguardian.com
Is Exenatide a Treatment for Parkinson’s Disease? Athauda, Dilan. Wyse, Richard. Brundin, Patrik. Foltynie, Thomas. Journal
Is Exenatide a Treatment for Parkinson’s Disease? Athauda, Dilan. Wyse, Richard. Brundin, Patrik. Foltynie, Thomas. Journal of Parkinson's Disease. "There is growing interest in the use of glucagon-like peptide-1
agonists as treatments for Parkinson’s disease following the recent
publication...
Source: iospress.com
Machines evaluating applicants? 'So what could admissions look like in 20 years? From a school’s perspective, automation
Machines evaluating applicants? 'So what could admissions look like in 20 years? From a school’s perspective, automation will take on a lot of the human-led work, according to Steve Farmer, Vice Provost for Enrollment and Undergraduate Admissions at the University of North Carolina.' Reports University...
Source: universitybusiness.com
NEJM Journal Watch Psychiatry Top Stories of 2016: On behalf of the editors of NEJM Journal Watch Psychiatry , I am pleased
NEJM Journal Watch Psychiatry Top Stories of 2016: On behalf of the editors of NEJM Journal Watch Psychiatry , I am pleased to present the Psychiatry Top Stories of 2016.
The selection of the 10 best stories was, as always, difficult, with more than 200 summaries published in the past year that inform...
Source: jwatch.org
In Celebration of Open Data | PLOS Biologue: It’s not every day I get to write something that is just fun. In celebration
In Celebration of Open Data | PLOS Biologue: It’s not every day I get to write something that is just fun. In celebration of OpenCon, and to recognise all of the fantastic articles that we’ve published at PLOS with a focus on Data Sharing across all of the PLOS journals, we’re really excited...
Source: plos.org
Evolution seems to have occurred a million times faster than natural selection alone could explain. Could nature be using
Evolution seems to have occurred a million times faster than natural selection alone could explain. Could nature be using some hidden process? Just read Probably Approximately Correct by Leslie Valiant (a computational theorist). It explores a special class of algorithms which he calls 'ecorthims' that...
Source: amazon.co.uk
Heart valve patients may benefit from managing own blood thinners: Allowing select patients to self-manage blood thinners
Heart valve patients may benefit from managing own blood thinners: Allowing select patients to self-manage blood thinners following heart valve surgery may lead to a lower risk of major complications, according to an article posted online by the Annals of Thoracic Surgery.
Source: medicalxpress.com
Jeremy Hunt accused of suppressing evidence on benefits of 'sugar tax': Health select committee chair questioned whether
Jeremy Hunt accused of suppressing evidence on benefits of 'sugar tax': Health select committee chair questioned whether political pressure had been applied to Hunt to prevent the release of important documents
Source: theguardian.com
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