Milasen - a drug developed for a single patient.
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease | NEJM: Summary Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the...
Source: nejm.org
After the morning after: what next for UK trade policy? - Trade Knowledge Exchange: In the aftermath of the UK General Elections,
After the morning after: what next for UK trade policy? - Trade Knowledge Exchange: In the aftermath of the UK General Elections, in which the Conservatives won 364 out of 650 seats in House of Commons, the question that arises is what this means for the UK and the EU. “Getting Brexit done” was,...
Source: trade-knowledge.net
People in Japan are wearing exoskeletons to keep working as they age: To solve the problem of Japan’s ageing workforce,
People in Japan are wearing exoskeletons to keep working as they age: To solve the problem of Japan’s ageing workforce, tech companies have developed exoskeletons that help older workers continue to do heavy manual labour
Source: newscientist.com
Cardiac guidelines challenged following investigation.
Surgeons withdraw support for heart disease advice: European guidelines on a form of heart disease are under review, following a Newsnight investigation. “It is a matter of serious concern to us that some results in the Excel trial appear to have been concealed and that some patients may therefore...
Source: bbc.com
Animated video can more cost-effectively reach the widest – even geographically isolated – populations, it readily
Animated video can more cost-effectively reach the widest – even
geographically isolated – populations, it readily complements extension
services and international development community efforts to secure
knowledge transfer and recipient buy-in for innovations. Implications
and future research...
Source: tandfonline.com
Archivists Are Trying to Make Sure a
Archivists Are Trying to Make Sure a ‘Pirate Bay of Science’ Never Goes Down: A new project aims to make LibGen, which hosts 33 terabytes of scientific papers and books, much more stable. "It’s hard to find free and open access to scientific material online. The latest studies and current research...
Source: vice.com
Would you pay $1 million to enroll in a phase 1 clinical trial of an
Would you pay $1 million to enroll in a phase 1 clinical trial of an “anti-aging” gene therapy? "Libella Gene Therapeutics, LLC made the news last week for announcing a “pay-to-play” trial of its telomerase-based anti-aging gene therapy. What was shocking about the announcement was not that it...
Source: sciencebasedmedicine.org
Video for learning
Video for learning is great at some things, not so great at others. Great summary of recent evidence from Donald Clark. What can we learn from Netflix? (Use technology appropriately not just the buzzwords) Episodic vs. Semantic memory (Remembering the right things from video isn't as easy as you think)...
Source: blogspot.com
A Promising Solar Energy Breakthrough Just Achieved 1,000-Degree Heat From Sunlight: A new startup backed by Bill Gates
A Promising Solar Energy Breakthrough Just Achieved 1,000-Degree Heat From Sunlight: A new startup backed by Bill Gates says it has managed to harness solar energy to greater effect than ever before, generating enough heat from a field of mirrored panels to drive the production of cement, steel and glass...
Source: sciencealert.com
'If you think competition is hard, you should try collaboration.'
Leading for integrated care: This report explores the progress, challenges and opportunities the move towards greater integration presents, through interviews with 16 people leading or chairing an integrated care system or sustainability and transformation partnership. "Under current plans all parts...
Source: kingsfund.org.uk
Effect of alcohol on promise making - a prisoner
An Economic Analysis of Business Drinking: Evidence from a Lab-in-the-field Experiment
“Our GAAM (guilt aversion and alcohol myopia) model predicts that intoxication increases promise-making but has no effect on promise-breaking. We test these predictions using a prisoner’s dilemma game with pre-play...
Source: gmu.edu
Dying with smartphones - the anthropology of our relationship with machines.
'Dying with smartphones' by Daniel Miller "The hospice movement has grown up respecting that most people want to die in their own homes, even when they are living alone. But where is that home?" "We have witnessed how smartphones are becoming part of us, rather than simply something we use. Humanity...
Source: wordpress.com
Why People Demanded Privacy to Confide in the World
"To encourage ongoing dialogue, Weizenbaum designed Eliza to simulate the type of conversational style used by a Rogerian psychoanalyst. The program would take something the user said and reflect it back with a question
... during their brief interactions with Eliza, many users began forming emotional...
Source: ieee.org
Micro-credientials - the toy model and other perspectives.
25 Years of EdTech: 2019 – Micro-credentials.
"... micro-credentials represent the latest chapter in the attempt to make the shape of higher education more amorphous and flexible. In this, I am in favour of them, because if you want education to be inclusive and diverse then it needs to come in...
Source: edtechie.net
The Distinctions Between Theory, Theoretical Framework, and Conceptual Framework
"Health professions education (HPE) researchers are regularly asked to articulate their use of theory, theoretical frameworks, and conceptual frameworks in their research. However, all too often, these words are used interchangeably or without a clear understanding of the differences between these concepts....
Source: lww.com
Autonomy, Belonging, Competence. GMC reports on the ABC of wellbeing.
Caring for doctors Caring for patients: An independent report into the wellbeing of UK medical students and doctors. "In 2018 we commissioned Professor Michael West and Dame Denise Coia, to carry out a UK-wide review to help tackle the causes of poor wellbeing faced by medical students and doctors.
...
Source: gmc-uk.org
City fund managers call for rethink of capitalism
"Two of the world’s biggest fund management bosses have called for a rethink of capitalism and its obsession with constant economic growth, in a plaintive appeal for business and governments to deal more decisively with the challenges of climate change.
Anne Richards, chief executive of Fidelity...
Source: www.ft.com
Eisai launches a digital health solution on Amazon Alexa for children with a rare form of epilepsy - Lennox-Gastaut Syndrome.
It marks the first time Pharmaceutical company Eisai has moved beyond medications and into digital health. The company’s Amazon Alexa skill – Ella the Jellyfish – has been developed for children with Lennox-Gastaut Syndrome (LGS) and was created with input from patients, their families and caregivers.
Source: epmmagazine.com
AI helps to improve radiologist performance.
In a multicenter study, radiologists had better performance with deep convolutional network software for the detection of malignant pulmonary nodules on chest radiographs than without. Deep Convolutional Neural Network-based Software Improves Radiologist Detection of Malignant Lung Nodules on Chest Radiographs....
Source: rsna.org
5 Features of Modern Workplace Learning
"5 Features of Modern Workplace Learning - Modern Workplace Learning 2020: There is a big mismatch between how individuals acquire new knowledge and skills and what they value (discovery, discourse and doing), and what organisations focus on and value (didactics). Modern Workplace Learning (MWL) is an...
Source: modernworkplacelearning.com
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