A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and
A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance - PubMed: This systematic review identifies and critically evaluates the mechanistic and clinical evidence of new promising therapeutic targets in hidradenitis...
Source: nih.gov
How novice and expert anaesthetists understand expertise in anaesthesia: a qualitative study: The development of expertise
How novice and expert anaesthetists understand expertise in anaesthesia: a qualitative study: The development of expertise in anaesthesia requires personal contact between a mentor and a learner. Because mentors often are experienced clinicians, they may find it difficult to understand the challenges...
Source: biomedcentral.com
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques: Severe acute respiratory syndrome coronavirus 2
ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 20191,2 and is responsible for the COVID-19 pandemic3. Vaccines are an essential countermeasure urgently needed to control the pandemic4. Here, we...
Source: nature.com
SARS-CoV-2-specific T cell immunity is seen in cases of COVID-19
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls: Memory T cells induced by previous pathogens can shape the susceptibility to, and clinical severity of, subsequent infections1. Little is known about the presence of pre-existing memory T cells in humans with...
Source: nature.com
5 simple questions to ask clinical AI vendors before you buy
Blog: 5 simple questions to ask clinical AI vendors before you buy — Hardian Health: Learn the five key questions you need to ask AI vendors, giving you the low-down on common marketing misunderstandings, statistical obfuscation, and creative stretching of medical device regulation.
Source: hardianhealth.com
Coronavirus COVID-19 SARS-CoV-2 information
A collection of information sources for COVID-19. The NHS 111 online COVID-19 service. The first point of call for someone in the UK who thinks they have symptoms or have been exposed whilst travelling. The NHS Coronavirus COVID-19 information webpage. UK Government's Coronavirus action plan. Public...
WhatsApp: A Real-Time Tool to Reduce the Knowledge Gap and Share the Best Clinical Practices in Psoriasis
WhatsApp: A Real-Time Tool to Reduce the Knowledge Gap and Share the Best Clinical Practices in Psoriasis: Abstract Background: Psoriasis is a chronic inflammatory disease that affects around 100 million people worldwide. The burden of disease is high, but more recent therapies show promising results....
Source: liebertpub.com
Diagnostic Tests for Syphilis Continue to Perplex Even the Experts
Diagnostic Tests for Syphilis Continue to Perplex Even the Experts: An Unanswerable Question in Infectious Diseases - HIV and ID Observations: Here’s a tricky clinical scenario: An elderly person with cognitive decline or some other non-specific neurologic symptom sees a clinician. Clinician sends...
Source: jwatch.org
Virtual reality technology for teaching neurosurgery of skull base tumor
Virtual reality technology for teaching neurosurgery of skull base tumor: Neurosurgery represents one of the most challenging and delicate of any surgical procedure. Skull base tumors in particular oftentimes present as a very technically difficult procedures in the setting of neurosurgical teaching....
Source: biomedcentral.com
Moore's outcomes framework and related papers
Outcomes-based planning for CME (Continuing Medical Education) often cites Donald Moore, Professor of Medical Education at Vanderbilt University. In 2009 he published an outcomes framework for CME (1) - which expanded George Miller's 1990 competency pyramid (2) - followed by a more detailed explanation...
Source: agnate.co.uk
Cardiac guidelines challenged following investigation.
Surgeons withdraw support for heart disease advice: European guidelines on a form of heart disease are under review, following a Newsnight investigation. “It is a matter of serious concern to us that some results in the Excel trial appear to have been concealed and that some patients may therefore...
Source: bbc.com
Would you pay $1 million to enroll in a phase 1 clinical trial of an
Would you pay $1 million to enroll in a phase 1 clinical trial of an “anti-aging” gene therapy? "Libella Gene Therapeutics, LLC made the news last week for announcing a “pay-to-play” trial of its telomerase-based anti-aging gene therapy. What was shocking about the announcement was not that it...
Source: sciencebasedmedicine.org
'If you think competition is hard, you should try collaboration.'
Leading for integrated care: This report explores the progress, challenges and opportunities the move towards greater integration presents, through interviews with 16 people leading or chairing an integrated care system or sustainability and transformation partnership. "Under current plans all parts...
Source: kingsfund.org.uk
Autonomy, Belonging, Competence. GMC reports on the ABC of wellbeing.
Caring for doctors Caring for patients: An independent report into the wellbeing of UK medical students and doctors. "In 2018 we commissioned Professor Michael West and Dame Denise Coia, to carry out a UK-wide review to help tackle the causes of poor wellbeing faced by medical students and doctors.
...
Source: gmc-uk.org
Publication bias is a challenge in science and a criticism of the influence of industry.
Publication bias is a challenge in science and a criticism of the influence of industry. In the domain of biosciences and drug development more accountability (e.g. the FDAAA 2007), editorial and peer-review training (as suggested by the Cochrane Collaboration), and statistical techniques (as championed...
Evaluation of Mobile Apps Targeted at Patients With Spondyloarthritis for Disease Monitoring: Systematic App Search.
Evaluation of Mobile Apps Targeted at Patients With Spondyloarthritis for Disease Monitoring. "A total of 1253 apps were identified in the app stores, and 5 apps met the criteria and were further analyzed. Moreover, 2 apps (MySpA and Group for Research and Assessment of Psoriasis and Psoriatic Arthritis...
Source: nih.gov
Factors associated with successful dementia education for practitioners in primary care: an in-depth case study.
Factors associated with successful dementia education for practitioners in primary care: an in-depth case study. Designing learning for person-centred care is challenging and needs to involve an approach that works with HCPs and interdisciplinary teams. “With increasing numbers of people in the UK...
Source: biomedcentral.com
Teaching a difficult topic in medical genetics using a problem-based concept resembling a computer game.
Teaching a difficult topic using a problem-based concept resembling a computer game: development and evaluation of an e-learning application for medical molecular genetics: E-learning through serious gaming. Teaching concepts such as genetic testing and the digital literacy required to analyse data can...
Source: biomedcentral.com
Physicians reported less burnout and emotional exhaustion after receiving short-term professional coaching.
Physicians reported less burnout and emotional exhaustion after receiving short-term professional coaching, according to a pilot trial published in JAMA Internal Medicine. Counseling Reduces Physician Burnout Anita Slomski. JAMA. 2019;322(16):1544 This editorial in JAMA comments on the recent paper:...
Source: jamanetwork.com
Change in clinical practice is slow even when it is obvious change should occur. Changing to a generic drug took 8 months
Change in clinical practice is slow even when it is obvious change should occur. Changing to a generic drug took 8 months and it was 18 months for adopting a guideline on UTI. "Substantial variation was observed in the speed with which individual NHS general practices responded to warranted changes...
Source: bmj.com
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