Milasen - a drug developed for a single patient.
Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease | NEJM: Summary Genome sequencing is often pivotal in the diagnosis of rare diseases, but many of these conditions lack specific treatments. We describe how molecular diagnosis of a rare, fatal neurodegenerative condition led to the...
Source: nejm.org
Autonomy, Belonging, Competence. GMC reports on the ABC of wellbeing.
Caring for doctors Caring for patients: An independent report into the wellbeing of UK medical students and doctors. "In 2018 we commissioned Professor Michael West and Dame Denise Coia, to carry out a UK-wide review to help tackle the causes of poor wellbeing faced by medical students and doctors.
...
Source: gmc-uk.org
Change in clinical practice is slow even when it is obvious change should occur. Changing to a generic drug took 8 months
Change in clinical practice is slow even when it is obvious change should occur. Changing to a generic drug took 8 months and it was 18 months for adopting a guideline on UTI. "Substantial variation was observed in the speed with which individual NHS general practices responded to warranted changes...
Source: bmj.com
Chimps bond with each other and people after watching a film together: Shared experiences make people feel closer - and
Chimps bond with each other and people after watching a film together: Shared experiences make people feel closer - and they also seem to help great apes bond with each other and with humans. The BBC also covered this study How chimpanzees bond over a movie together.
Source: newscientist.com
Frailty predicts mortality in all emergency surgical admissions regardless of age. An observational study: “Frail patients
Frailty predicts mortality in all emergency surgical admissions regardless of age. An observational study: “Frail patients in any age group are more likely to die than those that are not frail. We aimed to evaluate the impact of frailty on clinical mortality, readmission rate and length of stay for...
Source: oup.com
www.bmj.com | 521: Web server is down
www.bmj.com | 521: Web server is down
Source: bmj.com
Team-based learning (TBL) in the medical curriculum: better than PBL?: Internationally, medical schools have long used a
Team-based learning (TBL) in the medical curriculum: better than PBL?: Internationally, medical schools have long used a variety of approaches to develop hybrid Problem based learning (PBL) curricula. However, Team-based learning (TBL), has gained recent popularity in medical education. TBL maintains...
Source: biomedcentral.com
Early phase drug trial claims a breakthrough in Huntington disease. IONIS-HTT is an antisense "gene-silencing" compound,
Early phase drug trial claims a breakthrough in Huntington disease. IONIS-HTT is an antisense "gene-silencing" compound, injected in to CSF and designed to reduce the production of all forms of the huntingtin (HTT) protein, which in its mutated variant (mHTT) is responsible for Huntington's Disease....
Source: reuters.com
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost
Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis: Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral anticoagulants (DOACs) for patients with atrial fibrillation.
Design...
Source: bmj.com
Mind-Altering Cat Parasite Linked To a Whole Lot of Neurological Disorders - Slashdot: schwit1 shares a report from ScienceAlert:
Mind-Altering Cat Parasite Linked To a Whole Lot of Neurological Disorders - Slashdot: schwit1 shares a report from ScienceAlert: The brain-dwelling parasite Toxoplasma gondii is estimated to be hosted by at least 2 billion people around the world, and new evidence suggests the lodger could be more dangerous...
Source: slashdot.org
Using a videogame to facilitate nursing and medical students' first visit to the operating theatre. A randomized controlled
Using a videogame to facilitate nursing and medical students' first visit to the operating theatre. A randomized controlled trial. - PubMed - NCBI
"A videogame was developed, combining pictures and short videos, by which students are interactively instructed on acting at the surgical block. Moreover,...
Source: nih.gov
Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study:
Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study: Objective To investigate the association between active commuting and incident cardiovascular disease (CVD), cancer, and all cause mortality.
Design Prospective population based...
Source: bmj.com
Japan's 'golden coder' making games apps aged 82 - BBC News: Masako Wakamiya took up programming when she retired from her
Japan's 'golden coder' making games apps aged 82 - BBC News: Masako Wakamiya took up programming when she retired from her bank clerk job.
Source: bbc.co.uk
Why Roman Concrete Endured Thousands of Years of Seawater Pounding, While Ours Can't - ExtremeTech: Roman concrete's durability
Why Roman Concrete Endured Thousands of Years of Seawater Pounding, While Ours Can't - ExtremeTech: Roman concrete's durability and strength blows our own out of the water (in this case, literally). And after years of research, we're getting better at understanding why. It seems that the sea water may...
Source: extremetech.com
Gigabyte Announces Tiny PC More Powerful and Upgradeable Than Raspberry Pi - ExtremeTech: The Raspberry Pi has proven itself
Gigabyte Announces Tiny PC More Powerful and Upgradeable Than Raspberry Pi - ExtremeTech: The Raspberry Pi has proven itself to be a versatile little computer, and you can get them for pocket change. It's a bit light on power, though. Now, Gigabyte is preparing to launch a similar device called the GA-SBCAP3350.
Source: extremetech.com
Vegan advert claiming 'Humane milk is a myth' cleared by ASA - BBC News: Complaints from the dairy industry are dismissed
Vegan advert claiming 'Humane milk is a myth' cleared by ASA - BBC News: Complaints from the dairy industry are dismissed as vegan group's advert is given the green light.
Source: bbc.co.uk
Paediatric IBD patients not meeting recommended calcium & vitamin D intake: The study found that only 26.6% and 21.3% of
Paediatric IBD patients not meeting recommended calcium & vitamin D intake: The study found that only 26.6% and 21.3% of sufferers were achieving the current recommended intake of calcium and vitamin D respectively. Achieving the correct levels of calcium and vitamin D is essential for developing children,...
Source: eurekalert.org
Unhealthy Britain: half of adults walk less than a mile a day – survey: Poll commissioned by Cancer Research UK finds
Unhealthy Britain: half of adults walk less than a mile a day – survey: Poll commissioned by Cancer Research UK finds 52% of adults walk only 2,000 steps a day, figures described as ‘worrying’ and likely to increase cancer risk
Source: theguardian.com
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